Important Safety Information for Estradiol Cream
Estradiol Cream is a prescription medication that should only be used under the supervision of a licensed healthcare provider.
Important Safety Warning
Estrogens may increase the risk of:
- Endometrial cancer in women with a uterus when used without appropriate progestin therapy
- Stroke
- Blood clots
- Heart attack
- Dementia in certain postmenopausal women
Estradiol should be used at the lowest effective dose and for the shortest duration consistent with treatment goals.
Do Not Use Estradiol Cream If You:
- Have abnormal or unexplained vaginal bleeding
- Have a history of breast cancer or estrogen-dependent cancer unless specifically approved by your healthcare provider
- Have active or past blood clots, deep vein thrombosis (DVT), or pulmonary embolism
- Have had a stroke or heart attack
- Have liver disease
- Are pregnant or may become pregnant
- Have a known allergy to estradiol or any ingredient in the formulation
Before Using Estradiol Cream
Tell your healthcare provider if you:
- Have high blood pressure
- Have heart disease
- Have diabetes
- Have elevated cholesterol or triglycerides
- Have a history of migraines
- Have asthma
- Have epilepsy or seizure disorders
- Have lupus
- Have thyroid disorders
- Have endometriosis
- Have uterine fibroids
- Smoke or use tobacco products
- Are taking prescription medications, supplements, or hormone therapies
Common Side Effects
Possible side effects may include:
- Breast tenderness or breast pain
- Headache
- Nausea
- Vaginal irritation, itching, or discharge
- Abdominal bloating
- Fluid retention
- Mood changes
- Pelvic discomfort
Serious Side Effects
Seek medical attention immediately if you experience:
- Unusual vaginal bleeding
- Signs of a blood clot, including leg pain, swelling, chest pain, or shortness of breath
- Sudden vision changes or vision loss
- Severe headache
- Signs of a stroke, including weakness on one side of the body or difficulty speaking
- Yellowing of the skin or eyes (possible liver problems)
- Signs of a serious allergic reaction, including swelling, rash, or difficulty breathing
Additional Safety Information
- Use exactly as prescribed by your healthcare provider.
- Attend recommended follow-up appointments and routine screenings.
- Perform regular breast self-examinations and follow recommended mammogram schedules.
- Inform all healthcare providers that you are using estradiol therapy.
- Do not use more frequently or in greater amounts than prescribed.
- Keep out of reach of children.
Disclaimer
Results vary by individual. Estradiol Cream is not appropriate for everyone. This information does not replace professional medical advice. Consult your healthcare provider regarding the risks and benefits of hormone therapy and whether estradiol is appropriate for you.
